Protein Modification Reagents
Medchemexpress LLC 6-FAM-PEG3-azide | 412319-45-0 | 98.1% | C29H28N4O9 | 10MG
6-FAM-PEG3-Azide is a fluorescent labeling reagent composed of a 6-carboxyfluorescein (6-FAM) dye linked to an azide via a PEG3 spacer. It is designed for covalent conjugation to alkyne-functionalized partners using copper-catalyzed azide-alkyne cycloaddition (CuAAC) or strain-promoted azide-alkyne cycloaddition (SPAAC), enabling fluorescent labeling of oligonucleotides and other biomolecules.
- Fluorescent labeling with excitation 498 nm and emission 532 nm.
- PEG3 spacer improves water solubility and reduces steric hindrance.
- Azide functional group for CuAAC and SPAAC click chemistry.
- Solid, light yellow to yellow form stable when stored as powder at -20°C.
- High purity (~98.1%) suitable for analytical and labeling applications.
Medchemexpress LLC DSPE-N3 | 2839508-98-2 | 96.4% | 831.11 g·mol⁻¹ | C43H83N4O9P | 25 MG
DSPE-N3 is an azide-functionalized phospholipid used as a click-chemistry reagent in biochemical and nanotechnology research. It enables both copper-catalyzed and strain-promoted azide-alkyne cycloadditions for reliable conjugation of biomolecules, surface modification, and lipid nanoparticle functionalization.
- Azide-functionalized phospholipid enabling click chemistry conjugation.
- Compatible with CuAAC and SPAAC reaction conditions.
- Suitable for nanoparticle and surface functionalization applications.
- White to off-white solid with standard storage requirements.
- Soluble in DMSO with warming and sonication for formulation.
- High purity (~96.4%) appropriate for research use.
Medchemexpress LLC Biotin-PEG4-TFP ester | 2985664-57-9 | 97.8% | C27H37F4N3O8S | 100 MG
Biotin-PEG4-TFP ester is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. They exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Contains two different ligands connected by a linker
- Exploits the intracellular ubiquitin-proteasome system to selectively degrade target proteins
![eMolecules 1144106-65-9 | Bromo-PEG1-azide | Broadpharm194.032 | C4H8BrN3O | 95.000 | BrCCOCCN=[N+]=[N-] | 1g | 433947074](https://assets.fishersci.com/TFS-Assets/CCG/product-images/NC1691006.jpg-250.jpg)
eMolecules 1144106-65-9 | Bromo-PEG1-azide | Broadpharm194.032 | C4H8BrN3O | 95.000 | BrCCOCCN=[N+]=[N-] | 1g | 433947074
Bromo-PEG1-azide | Broadpharm | 1144106-65-9194.032 | C4H8BrN3O | 95.000 | BrCCOCCN=[N+]=[N-] | 1g | 433947074
![eMolecules 2639395-40-5 | PTAD-PEG4-Azide | Broadpharm539.546 | C22H33N7O9 | 95.000 | COc1cc(ccc1OCCNC(=O)CCOCCOCCOCCOCCN=[N+]=[N-])-n1c(=O)[nH][nH]c1=O | 250mg | 573896753](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502183599.JPG-250.jpg)
eMolecules 2639395-40-5 | PTAD-PEG4-Azide | Broadpharm539.546 | C22H33N7O9 | 95.000 | COc1cc(ccc1OCCNC(=O)CCOCCOCCOCCOCCN=[N+]=[N-])-n1c(=O)[nH][nH]c1=O | 250mg | 573896753
PTAD-PEG4-Azide | Broadpharm | 2639395-40-5539.546 | C22H33N7O9 | 95.000 | COc1cc(ccc1OCCNC(=O)CCOCCOCCOCCOCCN=[N+]=[N-])-n1c(=O)[nH][nH]c1=O | 250mg | 573896753
Medchemexpress LLC Dspe-peg4-dbco | 2112738-14-2 | MFCD30828684 | 95.0% | C71H116N3O15P | 10MG
DSPE-PEG4-DBCO is a lipid-polyethylene glycol conjugate bearing a dibenzocyclooctyne (DBCO) reactive group used for copper-free click chemistry and bioconjugation. It enables strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-functionalized partners, facilitating liposome functionalization, surface modification, and linker assembly in aqueous and physiological conditions.
- Provides a DBCO reactive handle for copper-free SPAAC.
- Contains a PEG4 spacer for improved solubility and reduced steric hindrance.
- Includes a lipid anchor for incorporation into lipid bilayers and liposomes.
- Suitable for bioconjugation under physiological conditions.
- High purity for consistent reaction performance.
Medchemexpress LLC TCO-PEG2-amine | 2141981-87-3 | 97.0% | C15H28N2O4 | 100 MG
TCO-PEG2-amine is a PEG-based PROTAC linker used in the synthesis of PROTACs. These molecules consist of two distinct ligands connected by a linker, where one targets an E3 ubiquitin ligase and the other targets the protein of interest. PROTACs function by harnessing the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- For research use only
Medchemexpress LLC Pomalidomide-5'-PEG8-C2-COOH | 2138440-78-3 | 98.2% | 697.73 | C32H47N3O14 | 50 MG
Pomalidomide-5'-PEG8-C2-COOH is an E3 ligase ligand-linker conjugate intended as a building block for proteolysis-targeting chimera (PROTAC) synthesis. The molecule combines a pomalidomide-derived warhead with an eight-unit polyethylene glycol (PEG8) spacer and a terminal two-carbon carboxylic acid for coupling, supplied as a high-purity solid for research use.
- Designed for PROTAC construction and E3 ligase engagement.
- Pomalidomide-derived warhead with PEG8 spacer and terminal carboxylic acid for conjugation.
- High reported purity suitable for synthetic applications.
- Soluble in DMSO at high concentration for stock solutions.
- Recommended long-term storage at low temperatures to preserve integrity.
Medchemexpress LLC Biotinyl-NH-PEG3-C3-amido-C3-COOH | 1202761-21-4 | 99.3% | 100 MG
Biotinyl-NH-PEG3-C3-amido-C3-COOH is a PEG-based PROTAC linker designed for use in the synthesis of PROTACs. This solid, white to off-white compound offers high purity and is intended for research applications.
- High purity of 99.25%
- PEG-based PROTAC linker
- Suitable for synthesis of PROTACs
- Soluble in DMSO and methanol
- For research use only
eMolecules 1374666-32-6 | MAL-PEG2-ACID | AstaTech | MFCD23726620 | 257.242 | C11H15NO6 | 95 | OC(=O)CCOCCOCCN1C(=O)C=CC1=O | 0.25g | 464144612
Ambeed | (2S3R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(((benzyloxy)(hydroxy)phosphoryl)oxy)butanoic acid | 250mg | 490530784 | A197511 | 175291-56-2 | MFCD00797870 | 511.467 | C26H26NO8P
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Medchemexpress LLC (S,R,S)-AHPC-PEG5-COOH | 2172820-14-1 | 99.8% | 25 MG
(S,R,S)-AHPC-PEG5-COOH is a synthesized E3 ligase ligand-linker conjugate designed for PROTAC technology. It incorporates an (S,R,S)-AHPC based VHL ligand and a 5-unit PEG linker. This compound targets the VHL protein, a key subunit of Cullin RING E3 ubiquitin ligase complexes, facilitating ubiquitination and subsequent proteasomal degradation of target proteins. It is intended for research use only.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates (S,R,S)-AHPC based VHL ligand
- Features a 5-unit PEG linker
- Utilized in PROTAC technology
- Recruits VHL protein to induce target protein degradation
- For research use only
- Appears as a colorless to off-white solid
- Store at -20°C under nitrogen
Medchemexpress LLC 3,6,9,12-tetraoxatridecan-1-amine | 85030-56-4 | 98.8% | 207.27 g/mol | C9H21NO4 | 5 G
m-PEG4-Amine is a methoxy-terminated polyethylene glycol (PEG4) linker with a terminal primary amine used as a cleavable linker for antibody-drug conjugates (ADCs) and as a PEG-based linker in PROTAC synthesis. The compound has CAS 85030-56-4, molecular weight 207.27 g/mol, and is typically supplied as a colorless to light yellow liquid.
- Primary amine functional group suitable for conjugation chemistry.
- Methoxy-terminated PEG4 spacer provides solubility and flexibility.
- Cleavable linker applications for ADC and PROTAC synthesis.
- Stable when stored protected from light at recommended temperatures.
- Colorless to light yellow liquid, easy to handle in solution-phase chemistry.